Platelet-Rich Plasma (PRP) in Aesthetic Dermatology

Authors

  • Malika Ladha, MD, FRCPC

Abstract

Platelet-rich plasma (PRP) has been used in the field of orthopedics since the 1970s for cartilage repair, bone grafting, and musculoskeletal healing. PRP is an autologous blood product composed of an increased concentration of platelets, and is defined as a “drug” by Health Canada.

In the last decade, this treatment modality has emerged in the aesthetic dermatologic therapeutic armamentarium. It has been gaining significant real-world popularity, likely boosted by social media and other forms of media. The purpose of this article is to review PRP in aesthetic dermatology.

Author Biography

Malika Ladha, MD, FRCPC

Dr. Malika Ladha is a board-certified dermatologist in both the U.S. and Canada, and practices medical and cosmetic dermatology in Toronto. She completed residency at the University of Calgary and a clinical fellowship in Laser Surgery and Aesthetic Dermatology at the University of Toronto. She was the previous co-chairperson of the Canadian Dermatology Association Resident and Fellow Society co-chairperson and initiated many national virtual learning initiatives. She was awarded the 2021 Resident Doctors of Canada Medical Education Award and the 2021 Royal College of Physicians Resident Leadership Award.

References

Xie X, Zhang C, Tuan RS. Biology of platelet-rich plasma and its clinical application in cartilage repair. Arthritis Res Ther. Feb 25 2014;16(1):204. doi:10.1186/ar4493

treatments HCcpoPRP. https://recalls-rappels.canada.ca/en/alert-recall/health-canada-clarifies-position-platelet-rich-plasma-treatments

Atiyeh B, Oneisi A, Ghieh F. Platelet-Rich Plasma Facial Rejuvenation: Myth or Reality? Aesthetic Plast Surg. 12 2021;45(6):2928-2938. doi:10.1007/s00266-021-02300-9

Emer J. Platelet-Rich Plasma (PRP): Current Applications in Dermatology. Skin Therapy Lett. Sep 2019;24(5):1-6.

Schoenberg E, Wang JV, Zachary CB, Saedi N. Treatment of acne scars with PRP and laser therapy: an up-to-date appraisal. Arch Dermatol Res. Oct 2019;311(8):643-646. doi:10.1007/s00403-019-01936-7

Alves R, Grimalt R. A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification. Skin Appendage Disord. Jan 2018;4(1):18-24. doi:10.1159/000477353

Abuaf OK, Yildiz H, Baloglu H, Bilgili ME, Simsek HA, Dogan B. Histologic Evidence of New Collagen Formulation Using Platelet Rich Plasma in Skin Rejuvenation: A Prospective Controlled Clinical Study. Ann Dermatol. Dec 2016;28(6):718-724. doi:10.5021/ad.2016.28.6.718

DeLong JM, Russell RP, Mazzocca AD. Platelet-rich plasma: the PAW classification system. Arthroscopy. Jul 2012;28(7):998-1009. doi:10.1016/j.arthro.2012.04.148

Dermatology AAo. https://www.aad.org/public/cosmetic/younger-looking/platelet-rich-plasma-secret-to-younger-skin

Redaelli A, Romano D, Marcianó A. Face and neck revitalization with platelet-rich plasma (PRP): clinical outcome in a series of 23 consecutively treated patients. J Drugs Dermatol. May 2010;9(5):466-72.

Schoenberg E, O’Connor M, Wang JV, Yang S, Saedi N. Microneedling and PRP for acne scars: A new tool in our arsenal. J Cosmet Dermatol. Jan 2020;19(1):112-114. doi:10.1111/jocd.12988

Wu N, Sun H, Sun Q, et al. A meta-analysis of fractional CO. Lasers Med Sci. Feb 2021;36(1):1-12. doi:10.1007/s10103-020-03105-z

Uebel CO, da Silva JB, Cantarelli D, Martins P. The role of platelet plasma growth factors in male pattern baldness surgery. Plast Reconstr Surg. Nov 2006;118(6):1458-1466. doi:10.1097/01.prs.0000239560.29172.33

Gupta AK, Carviel J. A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia. Dermatol Surg. Dec 2016;42(12):1335-1339. doi:10.1097/DSS.0000000000000901

Cervelli V, Garcovich S, Bielli A, et al. The effect of autologous activated platelet rich plasma (AA-PRP) injection on pattern hair loss: clinical and histomorphometric evaluation. Biomed Res Int. 2014;2014:760709. doi:10.1155/2014/760709

Gkini MA, Kouskoukis AE, Tripsianis G, Rigopoulos D, Kouskoukis K. Study of platelet-rich plasma injections in the treatment of androgenetic alopecia through an one-year period. J Cutan Aesthet Surg. 2014 Oct-Dec 2014;7(4):213-9. doi:10.4103/0974-2077.150743

Evans AG, Mwangi JM, Pope RW, et al. Platelet-rich plasma as a therapy for androgenic alopecia: a systematic review and meta-analysis. J Dermatolog Treat. Feb 2022;33(1):498-511. doi:10.1080/09546634.2020.1770171

Schoenberg E, Hattier G, Wang JV, Saedi N. Platelet-rich plasma for facial rejuvenation: An early examination. Clin Dermatol. 2020 Mar – Apr 2020;38(2):251-253. doi:10.1016/j.clindermatol.2019.06.003

Alam M, Hughart R, Champlain A, et al. Effect of Platelet-Rich Plasma Injection for Rejuvenation of Photoaged Facial Skin: A Randomized Clinical Trial. JAMA Dermatol. 12 01 2018;154(12):1447-1452. doi:10.1001/jamadermatol.2018.3977

Maisel-Campbell AL, Ismail A, Reynolds KA, et al. A systematic review of the safety and effectiveness of platelet-rich plasma (PRP) for skin aging. Arch Dermatol Res. Jul 2020;312(5):301-315. doi:10.1007/s00403-019-01999-6

VEINS PTOFD. PHLEBOTOMY: 5 TIPS ON FINDING DIFFICULT VEINS. https://phlebotomyu.com/phlebotomy-finding-difficult-veins/

Published

2022-12-01

How to Cite

1.
Ladha M. Platelet-Rich Plasma (PRP) in Aesthetic Dermatology. Can Dermatol Today [Internet]. 2022 Dec. 1 [cited 2024 Nov. 24];3(4):29–33. Available from: https://canadiandermatologytoday.com/article/view/3-4-ladha

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Section

Articles