Comorbidités de l’eczéma chez l’adulte
Qu’en est-il? Qu’est-ce qui compte?
Mots-clés :
eczema, psoriasis , dermatitisRésumé
L’observation selon laquelle le psoriasis pourrait être un facteur de risque indépendant d’infarctus du myocarde (IM), qui a été démontrée d’une manière particulièrement éloquente dans une étude de la population du Royaume-Uni publiée dans le JAMA, est à l’origine d’un flot constant d’études portant sur les comorbidités des maladies de la peau.
Le psoriasis, la dermatite atopique (eczéma), l’hidrosadénite suppurée, la pelade et d’autres affections ont fait l’objet d’études portant sur leurs liens avec diverses comorbidités extracutanées. Plus précisément, l’eczéma a fait l’objet d’études portant sur la santé mentale et les troubles du sommeil, les maladies cardiovasculaires, l’ostéoporose et le risque de fracture. Dans le présent article, je passe en revue les données relatives à certaines comorbidités de l’eczéma chez les adultes, et j’exprime mon opinion sur la possibilité que l’une ou l’autre puisse se répercuter sur la prise en charge de nos patients. Autrement dit, comptent-elles?
Références
Gelfand JM, Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006;296(14):1735-1741.
Silverberg JI, Garg NK, Paller AS, Fishbein AB, Zee PC. Sleep disturbances in adults with eczema are associated with impaired overall health: a US population-based study. The Journal of Investigative Dermatology. 2015;135(1):56-66.
Garg N, Silverberg JI. Association between eczema and increased fracture and bone or joint injury in adults: a US population-based study. JAMA dermatology. 2015;151(1):33-41.
Charman CR, Venn AJ, Williams HC. The patient-oriented eczema measure: development and initial validation of a new tool for measuring atopic eczema severity from the patients’ perspective. Arch Dermatol. 2004;140(12):1513-1519.
Guttman-Yassky E, Silverberg JI, Nemoto O, et al. Baricitinib in adult patients with moderate-to-severe atopic dermatitis: A phase 2 parallel, double-blinded, randomized placebo-controlled multiple-dose study. Journal of the American Academy of Dermatology. 2019;80(4):913-921 e919.
Simpson EL, Gadkari A, Worm M, et al. Dupilumab therapy provides clinically meaningful improvement in patient-reported outcomes (PROs): A phase IIb, randomized, placebo-controlled, clinical trial in adult patients with moderate to severe atopic dermatitis (AD). Journal of the American Academy of Dermatology. 2016;75(3):506-515.
Ronnstad ATM, Halling-Overgaard AS, Hamann CR, Skov L, Egeberg A, Thyssen JP. Association of atopic dermatitis with depression, anxiety, and suicidal ideation in children and adults: A systematic review and meta-analysis. Journal of the American Academy of Dermatology. 2018;79(3):448-456 e430.
Drucker AM, Thiruchelvam D, Redelmeier DA. Eczema and subsequent suicide: a matched case-control study. BMJ open. 2018;8(11):e023776.
McDonald K, Shelley A, Jafferany M. The PHQ-2 in Dermatology-Standardized Screening for Depression and Suicidal Ideation. JAMA Dermatology. 2017.
Thyssen JP, Halling-Overgaard AS, Andersen YMF, Gislason G, Skov L, Egeberg A. The association with cardiovascular disease and type 2 diabetes in adults with atopic dermatitis: a systematic review and meta-analysis. The British Journal of Dermatology. 2018;178(6):1272-1279.
Ascott A, Mulick A, Yu AM, et al. Atopic eczema and major cardiovascular outcomes: A systematic review and meta-analysis of population-based studies. The Journal of Allergy and Clinical Immunology. 2019;143(5):1821-1829.
Silverwood RJ, Forbes HJ, Abuabara K, et al. Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study. BMJ. 2018;361:k1786.
Zhang A, Silverberg JI. Association of atopic dermatitis with being overweight and obese: a systematic review and metaanalysis. Journal of the American Academy of Dermatology. 2015;72(4):606-616 e604.
Kantor R, Kim A, Thyssen JP, Silverberg JI. Association of atopic dermatitis with smoking: A systematic review and meta-analysis. Journal of the American Academy of Dermatology. 2016;75(6):1119-1125 e1111.
Drucker AM, Harvey PJ. Atopic dermatitis and cardiovascular disease: What are the clinical implications? The Journal of Allergy and Clinical Immunology. 2019;143(5):1736-1738.
Lowe KE, Mansfield KE, Delmestri A, et al. Atopic eczema and fracture risk in adults: A population-based cohort study. The Journal of Allergy and Clinical Immunology. 2019.
Drucker AM, Eyerich K, de Brun-Weller MS, et al. Use of systemic corticosteroids for atopic dermatitis: International Eczema Council consensus statement. The British Journal of Dermatology. 2018;178(3):768-775.
