Off-Label Uses of Topical Ruxolitinib

Auteurs-es

  • Parbeer Grewal

Résumé

Ruxolitinib cream has demonstrated significant promise in both approved and off-label dermatological indications. Its localized action, rapid symptom relief, and favourable safety profile make it an attractive alternative to systemic treatments. However, current evidence is limited by small sample sizes, short follow-up periods, and unoptimized dosing protocols. Addressing these gaps through larger-scale, long-term research will be critical to understanding its full potential as a safe and effective therapy for diverse inflammatory and autoimmune skin diseases.

Biographie de l'auteur-e

Parbeer Grewal

Originally from Fort McMurray, Alberta, Dr. Grewal now resides and practices dermatology in the community setting in Edmonton, Alberta. In 2002, Dr. Grewal completed his Bachelor of Science (BSc) undergraduate degree at the University of Alberta with a Specialization in Psychology and graduated with Distinction. He completed his Doctor of Medicine (MD) degree at the University of Alberta in 2006 and graduated with Special Training in Research. In 2011, he completed his Dermatology training at the University of Alberta and became a Fellow of the Royal College of Physicians and Surgeons of Canada (FRCPC) and also went on to become a board certified Fellow of the American Academy of Dermatology (FAAD). Dr. Grewal is a Clinical Professor within the Faculty of Medicine, Division of Dermatology, at the University of Alberta. He is the Co-Medical Director of Dermatology and Clinical Research Trials at Rejuvenation Dermatology and Aesthetics Downtown Edmonton. He is also a consulting physician for the University of Alberta Hospital, the Royal Alexandra Hospital, the Grey Nuns Hospital and the Misericordia Hospital. Dr. Grewal has participated in over 100 clinical research trials for a multitude of dermatology conditions and medications. Dr. Grewal also serves on multiple national and international scientific advisory boards, is a distinguished peer reviewer for medical journals and has published both journal articles and book chapters in Dermatology.

Références

Hoy, Sheridan M. 2023. “Ruxolitinib Cream 1.5%: A Review in Mild to Moderate Atopic Dermatitis.” American Journal of Clinical Dermatology 24 (1): 143–51.

Tavoletti, G., G. Avallone, C. Conforti, G. Roccuzzo, C. A. Maronese, M. A. Mattioli, P. Quaglino, et al. 2023. “Topical Ruxolitinib: A New Treatment for Vitiligo.” Journal of the European Academy of Dermatology and Venereology : JEADV 37 (11): 2222–30.

Gong, Xiaohua, Xuejun Chen, Michael E. Kuligowski, Xing Liu, Xiang Liu, Evan Cimino, Ryan McGee, and Swamy Yeleswaram. 2021. “Pharmacokinetics of Ruxolitinib in Patients with Atopic Dermatitis Treated With Ruxolitinib Cream: Data from Phase II and III Studies.” American Journal of Clinical Dermatology 22 (4): 555–66.

Hosking, Anna-Marie, Margit Juhasz, and Natasha Atanaskova Mesinkovska. 2018. “Topical Janus Kinase Inhibitors: A Review of Applications in Dermatology.” Journal of the American Academy of Dermatology 79 (3): 535–44.

Solimani F, Meier K, Ghoreschi K. Emerging Topical and Systemic JAK Inhibitors in Dermatology. Front Immunol. 2019;10:2847. Published 2019 Dec 3. doi:10.3389/ fimmu.2019.02847

Böll SL, Seyed Jafari SM, Conrad C, Schlapbach C. Topical Ruxolitinib and Delgocitinib Versus Systemic JAK Inhibitors: A Comparative Safety Review. Int J Mol Sci. 2025 Oct 30;26(21):10592. doi: 10.3390/ijms262110592. PMID: 41226626; PMCID: PMC12607478.

Carmona-Rocha E, Rusiñol L, Puig L. New and Emerging Oral/Topical Small-Molecule Treatments for Psoriasis. Pharmaceutics. 2024;16(2):239. Published 2024 Feb 6.

Punwani N, Scherle P, Flores R, Shi J, Liang J, Yeleswaram S, et al. . Preliminary Clinical Activity of a Topical JAK1/2 Inhibitor in the Treatment of Psoriasis. J Am Acad Dermatol. 2012;67(4):658-664. doi:10.1016/j. jaad.2011.12.018

Craiglow BG, Tavares D, King BA. Topical ruxolitinib for the treatment of alopecia areata. JAMA Dermatol. 2016;152(4):490–492. doi:10.1001/ jamadermatol.2015.4445

Bayart CB, DeNiro KL, Brichta L, Craiglow BG, Sidbury R. Topical Janus Kinase Inhibitors for the Treatment of Pediatric Alopecia Areata. J Am Acad Dermatol. 2017;77(1):167-170. doi:10.1016/j.jaad.2017.03.024

Gordon SC, Abudu M, Zancanaro P, Ko JM, Rosmarin D. Rebound effect associated with JAK inhibitor use in the treatment of alopecia areata. J Eur Acad Dermatol Venereol. 2019;33(4):e156-e157. doi:10.1111/jdv.15383

Deeb M, Beach RA. A Case of Topical Ruxolitinib Treatment Failure in Alopecia Areata. J Cutan Med Surg. 2017;21(6):562-563. doi:10.1177/1203475417716363

Olsen EA, Kornacki D, Sun K, Hordinsky MK. Ruxolitinib cream for the treatment of patients with alopecia areata: a 2-part, double-blind, randomized, vehicle-controlled phase 2 study. J Am Acad Dermatol. 2020;82(2):412-419. doi:10.1016/j.jaad.2019.10.016

Pope E, Kowalski E, Tausk F. Topical ruxolitinib in the treatment of refractory facial seborrheic dermatitis. JAAD Case Rep. 2022;24:59-60. Published 2022 Apr 23. doi:10.1016/j.jdcr.2022.04.003

Desai D, Nohria A, Lo Sicco K, Shapiro J. The use of topical ruxolitinib 1.5% cream in frontal fibrosing alopecia: a case report. JAAD Case Rep. 2024;50:141-143. Published 2024 May 4. doi:10.1016/j.jdcr.2024.04.03

Brumfiel CM, Patel MH, Severson KJ, Zhang N, Li X, Quillen JK, et al. Ruxolitinib cream in the treatment of cutaneous lichen planus: a prospective, open-label study. J Invest Dermatol. 2022;142(8):2109-2116.e4. doi:10.1016/j. jid.2022.01.015

Nugent S, Coromilas AJ, English JC 3rd, Rosenbach M. Improvement of necrobiosis lipoidica with topical ruxolitinib cream after prior nonresponse to compounded topical tofacitinib cream. JAAD Case Rep. 2022;29:25-26. Published 2022 Aug 27. doi:10.1016/j. jdcr.2022.08.028

Kashetsky N, Turchin I. Utilization of Topical Ruxolitinib in Dermatology: A Review. Skin Skin Therapy Lett. 2023;28(3):8-13.

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Publié

2026-09-25

Comment citer

1.
Off-Label Uses of Topical Ruxolitinib. Can Dermatol Today [Internet]. 25 sept. 2026 [cité 28 sept. 2026];7(3):30-4. Disponible à: https://canadiandermatologytoday.com/article/view/7-3-Grewal_et_al

Numéro

Volume 7, Issue 3, Summer 2026

Rubrique

Articles

Comment citer

1.
Off-Label Uses of Topical Ruxolitinib. Can Dermatol Today [Internet]. 25 sept. 2026 [cité 28 sept. 2026];7(3):30-4. Disponible à: https://canadiandermatologytoday.com/article/view/7-3-Grewal_et_al

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