Tildrakizumab in patients with metabolic syndrome: A novel approach

Authors

  • Parbeer Grewal, MD

Abstract

Tildrakizumab is a high-affinity, humanized, IgG1 k antibody targeting interleukin 23 p19 to treat patients with chronic plaque psoriasis. The Food and Drug Administration (FDA) approved ILUMYATM (tildrakizumab-asmn) for the treatment of adults with moderate-to-severe plaque psoriasis who are candidates for systemic therapy or phototherapy in March 2018 and it has also been approved in Australia, Japan and numerous European countries. The approved recommended dosage of ILUMYATM in the United States is a subcutaneous injection of 100 mg at Weeks 0, 4, and every 12 weeks thereafter. In Canada, tildrakizumab has not yet been approved for the treatment of moderate-to-severe plaque psoriasis.

This article presents a fictitious case study of a patient who may be a good candidate for tildrakizumab and provides an underlying rationale for the choice of tildrakizumab in this clinical scenario.

A 39-year-old male presents to the office for a repeat visit for severe psoriasis. He has had psoriasis for 6 years and has failed topical therapy, and oral systemic agents. His past medical history is significant for obesity, hypertension, and impaired fasting glucose tolerance. His current medications include a multi-vitamin and an angiotensin receptor blocker. His family history is significant for obesity, hypertension, diabetes, and myocardial infarction. He travels quite frequently for work and, therefore is not able to commit to a phototherapy schedule. In choosing a biologic therapy, the new class of anti-IL23p19 agents have distinct clinical advantages that may be beneficial for this type of patient. 

Author Biography

Parbeer Grewal, MD

Dr. Parbeer Grewal is the medical director at Rejuvenation Dermatology and Aesthetics in downtown Edmonton and is also an associate clinical professor at the University of Alberta in the division of dermatology. He obtained his undergraduate degree at the University of Alberta and also completed both his Doctor of Medicine (MD) degree and dermatology training at the University of Alberta too. He is also a consulting physician for the University of Alberta Hospital, the Royal Alexandra Hospital, the Grey Nuns Hospital and the Misericordia Hospital. Dr. Grewal has participated in over 60 clinical research trials for a multitude of dermatology conditions and medications. Dr. Grewal also serves on multiple national and international scientific advisory boards, is a distinguished peer reviewer for medical journals and has published both journal articles and book chapters in dermatology.

References

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Published

2021-03-01

How to Cite

1.
Grewal P. Tildrakizumab in patients with metabolic syndrome: A novel approach. Can Dermatol Today [Internet]. 2021 Mar. 1 [cited 2024 Nov. 9];2(s03):9–11. Available from: https://canadiandermatologytoday.com/article/view/2-s03-grewal

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