Au-delà du double menton : l’utilisation de l’acide désoxycholique pour réduire les graisses ailleurs que dans la région sous-mentonnière
Résumé
L’acide désoxycholique est un acide biliaire secondaire qui contribue à l’émulsification des lipides lors de l’absorption dans l’intestin. En 2015, Santé Canada a approuvé l’acide désoxycholique d’origine non animale, non humaine et synthétiquement dérivé (injection d’ADC : ATX-101; KYBELLA, Madison, New Jersey; BELKYRA, Canada et Suède; KYTHERA Biopharmaceuticals, Inc., Westlake Village, CA, acquis par Allergan, Inc.) pour le traitement de la rondeur modérée ou importante associée à la graisse sous-mentonnière. Disponible dans un flacon de 2 mL contenant une solution à 10 mg/mL, l’acide désoxycholique est injecté dans les zones affectées à raison de 0,2 cc par centimètre. Un à trois jours après avoir été injecté directement dans le tissu adipeux, l’acide désoxycholique provoque une adipocytolyse en perturbant de manière irréversible la membrane cellulaire des adipocytes. Une semaine après l’injection, on observe un recrutement des macrophages dans la zone, et au 28e jour, la présence de fibroblastes et de signes de néocollagénèse qui entraînent une réduction durable de l’adiposité dans la zone traitée.
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