Algorithme Thérapeutique Pour Les Patients Atteints De Psoriasis En Plaques D’Intensité Modérée Ou Grave : Recension Fondée Sur Des Données Probantes
Résumé
Le tildrakizumab est un anticorps monoclonal qui se lie de manière spécifique à la sous-unité p19 de l’interleukine-23 (IL-23). Il a été homologué dans plusieurs pays pour le traitement des adultes atteints d’une forme chronique de psoriasis en plaques, d’intensité modérée ou grave. La dose standard est de 100 mg par injection sous-cutanée, aux semaines 0 et 4, puis toutes les 12 semaines par la suite, bien qu’une dose de 200 mg administrée au même intervalle ait été homologuée dans quelques pays.
Le présent article a pour objet de passer en revue les données probantes actuellement disponibles concernant le recours au tildrakizumab pour le traitement des adultes atteints d’une forme chronique de psoriasis en plaques, d’intensité modérée ou grave. L’analyse détaillée se limitera aux études pivots et aux analyses a postériori.
Références
Tildrakizumab (Ilumya) Product Monograph. US FDA.
Tildrakizumab (Ilumya) Product Monograph. EMA.
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