Prurigo Nodulaire

Auteurs-es

  • Daniel Wong, MD, FRCPC

Résumé

Le prurigo nodulaire (PN) est une maladie chronique et inflammatoire de la peau, caractérisée par des nodules hyperkératosiques fermes et par un prurit intense et continuel. Il peut toucher les hommes et les femmes de tous âges. Le PN représente un lourd fardeau de morbidité, qui entraîne une réduction de la qualité de vie, l’apparition de troubles du sommeil, d’anxiété et de dépression. Pour de nombreux patients, le PN reste une affection difficile à maîtriser, et aucun médicament n’est actuellement approuvé au Canada pour son traitement. Cette situation pourrait cependant changer grâce aux études menées activement sur de nouveaux agents thérapeutiques.

 

Biographie de l'auteur-e

Daniel Wong, MD, FRCPC

Le Dr Daniel Wong est un dermatologue détenteur d’un certificat de spécialiste. Il a obtenu un baccalauréat en sciences médicales en étudiant la biochimie clinique à l’Université Western. Le Dr Wong a ensuite obtenu son doctorat en médecine à la même université. Il a effectué sa résidence de cinq ans en dermatologie à l’Université de Toronto et exerce actuellement au DermCare, au DerCafe et au Centre canadien de dermatologie de Toronto, au Canada. Il s’intéresse notamment au cancer de la peau, aux affections cutanées inflammatoires telles que le psoriasis, et à l’enseignement médical.

Références

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Williams KA, Huang AH, Betzberg M, Kwatra SG. Prurigo nodularis: Pathogenesis and management. J Am Acad Dermatol. 2020 Dec;83(6):1567-1575.

Huang AH, Williams KA, Kwatra SG. Prurigo nodularis: Epidemiology and clinical features. J Am Acad Dermatol. 2020 Dec;83(6):1559-1565.

Bolognia J, Schaffer JV, Cerroni L. Dermatology Fourth Edition. 2017 Oct;Section 2:115

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Willams KA, Roh YS, Brown I, Sutaria N, Bakhshi P, Choi J, Gabriel S, Chavda R, Kwatra SG Pathophysiology, diagnosis and pharmacological treatment of prurigo nodularis. Expert Rev Clin Pharmacol. 2021 Jan;14(1):67-77.

Qureshi AA, Abate LE, Yosipovitch G, Friedman AJ. A Systematic Review of Evidence-Based Treatments for Prurigo Nodularis. J Am Acad Dermatol. 2019 Mar;80(3):756-764.

Saraceno R, Chiricozzi A, Nisticò SP, et al. An occlusive dressing containing betamethasone valerate 0.1% for the treatment of prurigo nodularis. J Dermatolog Treat. 2010 Nov;21(6):363-6.

Siepmann D, Lotts T, Blome C, et al. Evaluation of the antipruritic effects of topical pimecrolimus in non-atopic prurigo nodularis: Results of a randomized, hydrocortisone controlled, double-blind phase II trial. Dermatology. 2014;227(4):353-360.

Ständer S, Luger T, Metze D. Treatment of prurigo nodularis with topical capsaicin. J Am Acad Dermatol. 2001;44(3):471-478.

Huang AH, Canner JK, Kang S, et al. Analysis of real-world treatment patterns in patients with prurigo nodularis. J Am Acad Dermatol. 2020 Jan;82(1):34-36.

Stoll DM, Fields JP, King LE. Treatment of Prurigo Nodularis: Use of cryosurgery and intralesional steroids plus lidocaine. J Derm Surg Onc. 1983;9(11):922-924.

Wong SS, Goh CL. Double-blind, right/ left comparison of calcipotriol ointment and betamethasone ointment in the treatment of prurigo nodularis. Arch Dermatol. 2000;136:807-808.

Hann SK, Cho MY, Park YK. UV treatment of generalized prurigo nodularis. Int J Dermatol. 1990 Jul-Aug;29(6):436-7.

Rombold S, Lobisch K, Katzer K, Grazziotin TC, Ring J, Eberlein B. Efficacy of UVA1 phototherapy in 230 patients with various skin diseases. Photodermatology, Photoimmunology & Photomedicine. 2008;24(1):19–23.

Brenninkmeijer EEA, Spuls PI, Lindeboom R, Van Der Wal AC, Bos JD, Wolkerstorfer A. Excimer laser vs clobetasol propionate 0.05% ointment in prurigo form of atopic dermatitis: a randomized controlled trial, a pilot. Br J Dermatol. 2010;163:823-831.

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Klejtman T, Beylot-Barry M, Joly P, et al. Treatment of prurigo with methotrexate: a multicentre retrospective study of 39 cases. J Eur Acad Dermatol Venereol. 2018;32:437-440.

Siepmann D, Luger TA, Stander S. Antipruritic effect of cyclosporine microemulsion in prurigo nodularis: results of a case series. J Dtsch Dermatol Ges. 2008;6:941-946.

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Zalaudek I, Petrillo G, Baldassarre MA, et al. Amitriptyline as therapeutic and not symptomatic approach in the treatment of prurigo nodularis: a pilot study. G Ital Dermatol Venereol. 2006;141:433-437.

Stander S, Bockenholt B, Schurmeyer- Horst F, et al. Treatment of chronic pruritus with the selective serotonin re-uptake inhibitors paroxetine and fluvoxamine: results of an open-labelled, two-arm proof-of-concept study. Acta Derm Venereol. 2009;89:45-51.

Jaller J, Yosipovitch G. Successful treatment of epidermal nevus-associated pruritus with topical ketamineeamitriptylinee lidocaine. Acta Derm Venereol. 2018;98:121-122.

Stander S, Kwon P, Luger T. A randomized, double-blind, placebo-controlled, study of the neurokinin-1 receptor (nk1-r) antagonist serlopitant in subjects with prurigo nodularis (PN). Paper presented at: American Academy of Dermatology Annual Meeting. 2017 March 3-7.

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Stander S, Yosipovitch G, Legat FJ, Lacour JP, Paul C, Narbutt J, et al. Trial of Nemolizumab in Moderate-to-Severe Prurigo Nodularis. N Engl J Med. 2020 Feb;382(8):706-716.

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Park B. Nemolizumab Gets Breakthrough Therapy Status for Prurigo Nodularis empr.com2019 [updated December 9; cited 2021, Aug 25]. Available from: https://www.empr.com/home/news/nemolizumab-gets-breakthrough-therapy-status-forprurigo-nodularis.

https://www.fda.gov/patients/fast-track-breakthrough-therapy-accelerated-approval-priority-review/breakthrough-therapy

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Publié

2021-12-01

Comment citer

1.
Prurigo Nodulaire. Can Dermatol Today [Internet]. 1 déc. 2021 [cité 19 mars 2026];2(4):27–33. Disponible à: https://canadiandermatologytoday.com/article/view/2-4-wong

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Comment citer

1.
Prurigo Nodulaire. Can Dermatol Today [Internet]. 1 déc. 2021 [cité 19 mars 2026];2(4):27–33. Disponible à: https://canadiandermatologytoday.com/article/view/2-4-wong