An Update on Complications from Fillers
Abstract
Filler injections are one of the most popular cosmetic procedures performed worldwide in part due to their ease of use, as well as efficacy and safety. However, complications can occur, and it is important for injecting practitioners to have a thorough knowledge of these complications to both prevent and manage adverse events.
References
Alam M, Gladstone H, Kramer EM, et al. Dermatol. Surg. 2008;34 (Suppl. 1):S115–48.
Funt D, Pavicic T. Dermal fillers in aesthetics: an overview of adverse events and treatment approaches. Clin. Cosmet. Investig. Dermatol. 2013;6:295–316.
Jones D, Tezel A, Borell M. In-vitro resistance to degradation of HA by ovine testicular hyaluronidase. Dermatol Surg. 2010;36(s1):804–9.
De Lorenzi C. New High Dose Pulsed Hyaluronidase Protocol for Hyaluronic Acid Filler Vascular Adverse Events. Aesthet Surg J. 2017;37(7):814-25.
Jones D, Chopra R, Hee CK, et al. In-vivo degradation of hyaluronic acid (HA)-based fillers by exogenous hyaluronidases. Presented at the American Society for Dermatologic Surgery Annual Meeting (10–13 November 2016), New Orleans, LA.
Landau M. Hyaluronidase caveats in treating filler complications. Dermatol Surg 2015;41(Suppl 1):S347–S353.
Keller EC, Kaminer MS, Dover JS. Use of hyaluronidase in patients with bee allergy. Dermatol Surg. 2014;40:1145–7.
Glashofer MD, Flynn TC. Complications of temporary fillers. In: Carruthers J, Carruthers A. Soft Tissue Augmentation. Toronto: Elsevier Saunders. 2013;179-187.
Beleznay K, Carruthers JA, Carruthers A, Mummert ME, Humphrey S. Delayed-onset nodules secondary to a smooth cohesive 20 mg/mL hyaluronic acid filler: cause and management. Dermatol Surg. 2015;41:929–39.
Alijotas-Reig J, Fernandez-Figueras MT, Puig L. Inflammatory, immune-mediated adverse reactions related to soft tissue dermal fillers. Semin Arthritis Rheum. 2013;43:241–58.
Ledon JA, Savas JA, Yang S, et al. Inflammatory nodules following soft tissue filler use: a review of causative agents, pathology and treatment options. Am J Clin Dermatol. 2013;14:401-11.
Baeva LF, Lyle DB, Rios M, Langone JJ, et al. Different molecular weight hyaluronic acid effects on human macrophage interleukin 1B production. J Biomed Mater Res A. 2013;102A:305-14.
Beleznay K, Carruthers J, Humphrey S, Jones D. Avoiding and treating blindness from fillers: a review of the world literature. Dermatol Surg. 2015;41(10):1097-1117.
Larrabee WF, Makielski KH, Henderson JL. Surgical Anatomy of the Face, 2. Philadelphia: Lippincott Williams & Wilkins. 2004;97–101.
Flowers FP, Breza TS. Surgical anatomy of the head and neck. In: Bolognia JL, Jorizzo JL, Schaffer JV, editors. Dermatology 3. China: Elsevier. 2012;2235–6.
Kleintjes WG. Forehead anatomy: arterial variations and venous link of the midline forehead flap. J Plast Reconstr Aesthet Surg. 2007;60(6):593-606.
Saban Y, Andretto Amodeo C, Bouaziz D, Polselli R, etal. Nasal arterial vasculature: medical and surgical applications. Arch Facial Plast Surg. 2012;14:429-36.
Beleznay K, Humphrey S, Carruthers J, Carruthers A. Vascular compromise from soft tissue augmentation: experience with 12 cases and recommendations for optimal outcomes. J Clin Aesthet Dermatol. 2014;7:37–43.
DeLorenzi C. Complications of injectable fillers, part 2: vascular complications. Aesthet Surg J. 2014;34:584-600.
Tobalem S, Schutz JS, Chronopoulos A. Central retinal artery occlusion – rethinking retinal survival time. BMC Ophthalmol. 2018;18(1):101.
Beleznay K, Carruthers JDA, Humphrey S, Carruthers A, Jones D. Update on Avoiding and Treating Blindness From Fillers: A Recent Review of the World Literature. Aesthet Surg J. 2019;39:662-74.
